The Regina Qu'Appelle Health Region includes 17 First Nations communities and several Métis locals. First Nations include:

• Carry the Kettle First Nation
  
• Cowessess First Nation
  
• Day Star First Nation
  
• Gordon First Nation
  
• Kahkewistahaw First Nation
  
• Kawacatoose First Nation
  
• Little Black Bear First Nation
  
• Muscowpetung First Nation
  
• Muskowekwan First Nation
  
• Ochapowace First Nation
  
• Okanese First Nation
  
• Pasqua First Nation
  
• Peepeekisis First Nation
  
• Piapot Cree Nation
  
• Sakimay First Nation
  
• Standing Buffalo Dakota First Nation
  
• Star Blanket Cree Nation

Dialects spoken in these First Nations include:

• Cree
• Saulteaux
• The Sioux languages of Dakota/Lakota/Nakota
• Michif